PTD-DBM 0.002% Hair Regrowth Serum (1 Month Supply)

PTD-DBM 0.002% Hair Regrowth Serum (1 Month Supply)

Each bottle comes with a dropper and spray nozzle for easy scalp application with any hair length

Ingredients: Distilled Water, DMSO, Peppermint Oil, PTD-DBM

Directions: Apply to the scalp once daily. Keep out of reach of children.

Protein transduction domain (PTD) Dvl-binding motif (DBM) peptide.

PTD-DBM

PTD-DBM, also known as Protein Transduction Domain – Dvl Binding Motif, is a peptide that has researched as a treatment for androgenic alopecia. PTD-DBM acts on the Wnt pathway. The Wnt/β-catenin pathway has a role in hair follicle regeneration, and this pathway is regulated and inhibited by CXXC5 protein. The CXXC5 protein is encoded by the CXXC5 gene, and acts by binding to DNA and protein to protein interactions. The epigenetic factor with CXXC5 is what we see with how androgenic alopecia, or hair loss is often passed down from one generation to the next. Androgenic Alopecia was once believed to be a DHT problem, but we now know it is much more complex than this. If correcting hair loss was as simple as lowering or blocking DHT, hair loss would have been cured long ago.

It has been shown that when CXXC5 binds to Dishevelled proteins in the scalp, hair follicle growth is inhibited. PTD-DBM works by disrupting the CXXC5 – Dishevelled interaction, allowing new hair growth to take place. As previously mentioned, PTD-DBM works through the WNT/β-Catenin pathway, and this plays a role in hair regeneration through wound healing and collagen deposition. When studying PTD-DBM, researchers created wounds in the scalps of mice to induce their natural follicle regeneration.

The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing – PMC (nih.gov)

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis (jidonline.org)

South Korean scientist claims to have found cure for baldness (ibtimes.sg)