PTD-DBM / Valproic Acid Hair Regrowth Serum Combo (1 Month Supply)

PTD-DBM / Valproic Acid Hair Regrowth Serum Combo (1 Month Supply)

Each bottle comes with a dropper and spray nozzle for easy scalp application with any hair length.

PTD-DBM 0.002% Hair Regrowth Serum

Ingredients: Distilled Water, DMSO, Peppermint Oil, PTD-DBM

Directions: Apply to the scalp once daily. Keep out of reach of children.

Protein transduction domain (PTD) Dvl-binding motif (DBM) peptide.

Valproic Acid 8% Hair Regrowth Serum

Valproic Acid (VPA) inhibits glycogen synthase kinase 3β and activates the Wnt/β-catenin pathway, which is associated with the hair growth cycle and anagen induction.

Ingredients: Distilled Water, DMSO, Valproic Acid, Peppermint Oil

Directions: Apply to the scalp once daily. Keep out of reach of children.

PTD-DBM

PTD-DBM, also known as Protein Transduction Domain – Dvl Binding Motif, is a peptide that has researched as a treatment for androgenic alopecia. PTD-DBM acts on the Wnt pathway. The Wnt/β-catenin pathway has a role in hair follicle regeneration, and this pathway is regulated and inhibited by CXXC5 protein. The CXXC5 protein is encoded by the CXXC5 gene, and acts by binding to DNA and protein to protein interactions. The epigenetic factor with CXXC5 is what we see with how androgenic alopecia, or hair loss is often passed down from one generation to the next. Androgenic Alopecia was once believed to be a DHT problem, but we now know it is much more complex than this. If correcting hair loss was as simple as lowering or blocking DHT, hair loss would have been cured long ago.

It has been shown that when CXXC5 binds to Dishevelled proteins in the scalp, hair follicle growth is inhibited. PTD-DBM works by disrupting the CXXC5 – Dishevelled interaction, allowing new hair growth to take place. As previously mentioned, PTD-DBM works through the WNT/β-Catenin pathway, and this plays a role in hair regeneration through wound healing and collagen deposition. When studying PTD-DBM, researchers created wounds in the scalps of mice to induce their natural follicle regeneration.

The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing – PMC (nih.gov)

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis (jidonline.org)

South Korean scientist claims to have found cure for baldness (ibtimes.sg)

Valproic Acid

In male patients with androgenic alopecia, valproic acid spray treatment for 24 weeks significantly increased total hair count when compared to a placebo spray. Treatment with Valproic Acid spray twice a day for 24 weeks increased linear hair growth rate and hair density. Valproic Acid was also found to inhibit glycogen synthase kinase 3ß and activation of WNT/β-Catenin pathway, which resulted in hair follicle regeneration. When studying PTD-DBM, researchers added topical Valproic Acid and, it was noted that the hair regeneration effects of each were greatly enhanced when compared to treatment alone.

Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis – PubMed (nih.gov)